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Influence of acetylator phenotype on antidepressant effects of phenelzine.
Br J Psychiatry ; 141: 243-8, 1982 Sep.
Article in En | MEDLINE | ID: mdl-6753997
Acetylator phenotype, determined by blood levels after sulphadimidine, was related to outcome in a controlled trial of phenelzine in patients with depression and mixed anxiety depression. Slow acetylators showed more improvement and greater phenelzine-placebo differences than did fast acetylators, at two, four and six weeks. A tendency towards faster acetylation was observed in subjects with previous increased alcohol intake. Acetylator phenotype was not related to other symptom, diagnostic or history data.
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Collection: 01-internacional Database: MEDLINE Main subject: Anxiety Disorders / Phenelzine / Depressive Disorder Type of study: Clinical_trials Limits: Humans Language: En Journal: Br J Psychiatry Year: 1982 Document type: Article Country of publication: Reino Unido
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Collection: 01-internacional Database: MEDLINE Main subject: Anxiety Disorders / Phenelzine / Depressive Disorder Type of study: Clinical_trials Limits: Humans Language: En Journal: Br J Psychiatry Year: 1982 Document type: Article Country of publication: Reino Unido