Influence of acetylator phenotype on antidepressant effects of phenelzine.
Br J Psychiatry
; 141: 243-8, 1982 Sep.
Article
in En
| MEDLINE
| ID: mdl-6753997
Acetylator phenotype, determined by blood levels after sulphadimidine, was related to outcome in a controlled trial of phenelzine in patients with depression and mixed anxiety depression. Slow acetylators showed more improvement and greater phenelzine-placebo differences than did fast acetylators, at two, four and six weeks. A tendency towards faster acetylation was observed in subjects with previous increased alcohol intake. Acetylator phenotype was not related to other symptom, diagnostic or history data.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Anxiety Disorders
/
Phenelzine
/
Depressive Disorder
Type of study:
Clinical_trials
Limits:
Humans
Language:
En
Journal:
Br J Psychiatry
Year:
1982
Document type:
Article
Country of publication:
Reino Unido