Effects of methylphenidate on the fixed-ratio performance of mentally retarded children.
Pharmacol Biochem Behav
; 18(4): 541-4, 1983 Apr.
Article
in En
| MEDLINE
| ID: mdl-6867060
ABSTRACT
The effects of methylphenidate on the lever-pressing of 12 mentally retarded children maintained under fixed-ratio 5, 10 and 20 schedules of food delivery were examined. For five children, methylphenidate at oral doses of 0.3, 0.7 and 1.0 mg/kg produced generally dose-dependent decreases in response rates, whereas for the other seven children the two lower doses increased response rates while the highest dose decreased responding. The differential effects of methylphenidate across participants could not be attributed to differences in control response rates or demographic factors. However, each child whose rate of fixed-ratio responding was increased by methylphenidate also demonstrated a therapeutic response to the drug.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Conditioning, Operant
/
Intellectual Disability
/
Methylphenidate
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Language:
En
Journal:
Pharmacol Biochem Behav
Year:
1983
Document type:
Article
Publication country:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA