Have deoxystreptamine aminoglycoside antibiotics the same binding site on bacterial ribosomes?
J Antibiot (Tokyo)
; 33(8): 895-9, 1980 Aug.
Article
in En
| MEDLINE
| ID: mdl-7000739
ABSTRACT
(3H) Tobramycin was used as a probe to determine the relationship between the structure of aminoglycoside antibiotics and their ability to remove this drug from its higher affinity binding site on the ribosome. The dissacharide moieties (neamine, tobramine, gentamine) appeared to have a common binding site, whereas the kanosamine, garosamine and ribose moieties determined the specificity of this binding. Amikacin and butikacin behaved in an anomalous manner in spite of their close structural relationship to tobramycin.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ribosomes
/
Bacteria
/
Anti-Bacterial Agents
Language:
En
Journal:
J Antibiot (Tokyo)
Year:
1980
Document type:
Article