[Effect of cortisol, malnutrition and orchiectomy on the concentration of proteins and nucleic acids in rat liver]. / Efectos del cortisol, malnutrición y orquidectomía en la concentración de proteínas y ácidos nucleicos en hígado de rata.

ABSTRACT

Cortisol action on some hepatic parameters related to protein synthesis has been studied in normal and orchidectomized male rats. Since cortisol causes an intake reduction, pair-feeding runs were conducted to achieve results of the hormone action unbiased by the effects derived from the intake restriction. Administration of cortisol in doses of 0.8 mg/100 g of body weight/day to rats from weaning up to 30 days produced a significant increase in DNA and cell liver numbers and a decrease in proteins/DNA, cellular weight and RNA/DNA in unorchidectomized rats. While in orchidectomized rats these parameters do not vary. The intake restriction that cortisol provokes, produced a significant reduction in protein content, proteins/DNA, cellular weight and RNA/DNA. An increase in DNA and cell numbers in unorchidectomized rats, while in orchidectomized rats produced a reduction greater in DNA and cell numbers and an increase in RNA/DNA. Orchidectomy in control rats determined a decrease in protein liver content, DNA, proteins/DNA, cell numbers and cellular weight.