CMDBS, functional analogue of heparin sulfate as a new class of corneal ulcer healing agents.
Ophthalmic Res
; 26(6): 325-31, 1994.
Article
in En
| MEDLINE
| ID: mdl-7536320
ABSTRACT
Soluble dextran polymer derivatives (CMDBSs) are originally synthesized as heparin-like plasma substitutes. Some of them mimic heparin in its interactions and stabilize, protect and facilitate actions of heparin binding growth factors. The wound healing activity of one specific CMDBS was studied in a model of corneal ulcer on the rabbit eye and compared with the activity of basic fibroblast growth factors (bFGF) added alone or in association with CMDBS. Total reepithelization was observed with bFGF + CMDBS, bFGF alone and CMDBS alone after, respectively, 3.8 +/- 0.78, 4.3 +/- 0.67 and 4.4 +/- 0.51 days. All treatments were efficient if compared with eyes treated with saline (p < 0.0001). The grade of significance of the applied treatments was as follows bFGF + CMDBS > bFGF > CMDBS > saline. Our study pinpoints that some specific CMDBS are as potent agents as bFGF for corneal ulcer healing, and can therefore be proposed for therapeutic use.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Wound Healing
/
Corneal Ulcer
/
Dextrans
/
Heparitin Sulfate
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Ophthalmic Res
Year:
1994
Document type:
Article
Affiliation country:
Francia