Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth.
Cell
; 83(2): 313-22, 1995 Oct 20.
Article
in En
| MEDLINE
| ID: mdl-7585948
ABSTRACT
Ciliary neurotrophic factor (CNTF) supports motor neuron survival in vitro and in mouse models of motor neuron degeneration and was considered a candidate for the muscle-derived neurotrophic activity that regulates motor neuron survival during development. However, CNTF expression is very low in the embryo, and CNTF gene mutations in mice or human do not result in notable abnormalities of the developing nervous system. We have generated and directly compared mice containing null mutations in the genes encoding CNTF or its receptor (CNTFR alpha). Unlike mice lacking CNTF, mice lacking CNTFR alpha die perinatally and display severe motor neuron deficits. Thus, CNTFR alpha is critical for the developing nervous system, most likely by serving as a receptor for a second, developmentally important, CNTF-like ligand.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Central Nervous System
/
Receptors, Nerve Growth Factor
/
Motor Neurons
/
Nerve Growth Factors
/
Nerve Tissue Proteins
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Cell
Year:
1995
Document type:
Article
Affiliation country:
Estados Unidos