The mRNA-binding protein COLBP is glutamate dehydrogenase.
FEBS Lett
; 367(3): 291-6, 1995 Jul 03.
Article
in En
| MEDLINE
| ID: mdl-7607326
ABSTRACT
Expression of the liver-type isopeptides of cytochrome c oxidase is regulated post-transcriptionally. An RNA-binding activity has been found in only those cells where the liver-type subunits are detected. This binding protein, termed COLBP, recognises sequences or structures within the 3'-untranslated regions of transcripts encoding these liver-type isopeptides and has been implicated in the modulation of mRNA expression. We now show by subcellular fractionation, immunocompetition, UV-crosslinking and shift-Western studies that the metabolic enzyme glutamate dehydrogenase, previously reported as being able to bind RNA, is the cytochrome c oxidase transcript-binding protein, COLBP.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
RNA, Messenger
/
RNA-Binding Proteins
/
Electron Transport Complex IV
/
Glutamate Dehydrogenase
/
Liver
Limits:
Animals
Language:
En
Journal:
FEBS Lett
Year:
1995
Document type:
Article
Affiliation country:
Reino Unido