PADGEM/GMP-140 expression on platelet membranes from homozygous beta thalassaemic patients.
Br J Haematol
; 84(1): 111-7, 1993 May.
Article
in En
| MEDLINE
| ID: mdl-7687856
Thromboembolic events, which are associated with significant morbidity and mortality, occur in beta-thalassaemia. We studied the expression of the platelet selectin PADGEM/GMP-140 on intact cells from thalassaemic patients, as a marker of in vivo platelet activation. The mean of positive cells (%) was 38.143 +/- 20.65 in the patients versus 5.048 +/- 1.8 in the controls, n = 21, P < 0.001. No correlation was found between GMP-140 expression and splenectomy, platelet counts, plasma ferritin and natural coagulation inhibitors. Instead an indirect correlation was found between GMP-140 expression and HDL-cholesterol. Moreover platelet activation was directly correlated with pre-beta lipoproteins. Our data indicate that thalassaemic patients present an in vivo platelet activation, which possibly depends on the dyslipidaemia, which is now regarded as a frequent feature of this disease.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Platelets
/
Platelet Membrane Glycoproteins
/
Platelet Activation
/
Beta-Thalassemia
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
En
Journal:
Br J Haematol
Year:
1993
Document type:
Article
Affiliation country:
Italia
Country of publication:
Reino Unido