Cycloocta[b]pyran derivatives with local anesthetic, platelet antiaggregating and other activities.
Farmaco
; 50(1): 55-9, 1995 Jan.
Article
in En
| MEDLINE
| ID: mdl-7702722
ABSTRACT
The synthesis of some N,N-disubstituted 4-amino-5,6,7,8,9,10-hexahydro-3- phenyl-2H-cycloocta[b]pyran-2-ones by reaction of phenylchloroketene with a series of N,N-disubstituted 2-aminomethylenecyclooctanones, followed by dehydrochlorination in situ of the primary adducts with DBN, is described. The dimethylamino derivative showed a local anesthetic activity in mice superior to that of lidocaine, and some compounds exhibited a platelet antiaggregating activity in vitro superior or comparable to that of acetylsalicylic acid, as well as weak antiarrhythmic and antiinflammatory activities in rats.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyrans
/
Platelet Aggregation Inhibitors
/
Anti-Inflammatory Agents, Non-Steroidal
/
Anesthetics, Local
/
Anti-Arrhythmia Agents
Limits:
Animals
/
Humans
Language:
En
Journal:
Farmaco
Journal subject:
FARMACOLOGIA
/
QUIMICA
Year:
1995
Document type:
Article
Affiliation country:
Italia