Intestinal T-cell lymphoma with massive tissue and blood eosinophilia mediated by IL-5.
Leuk Lymphoma
; 17(1-2): 155-61, 1995 Mar.
Article
in En
| MEDLINE
| ID: mdl-7773153
A case of enteropathy associated T-cell lymphoma (EATCL) in a 62-year-old female with a previous history of coeliac disease, complicated during the clinical course by massive blood and tissue eosinophilia is described. The patient's serum contained a factor capable of stimulating the in vitro growth of eosinophilic colonies (CFU-Eo), that was absent in the serum of normal donors. We suggest that such factor was Interleukin-5 (IL-5), as indicated by the presence in the monoclonal tumor T cells of IL-5 encoding mRNA, usually absent in the normal enterocytes of the jejunum.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lymphoma, T-Cell
/
Interleukin-5
/
Eosinophilia
/
Intestinal Neoplasms
Limits:
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Leuk Lymphoma
Journal subject:
HEMATOLOGIA
/
NEOPLASIAS
Year:
1995
Document type:
Article
Affiliation country:
Italia
Country of publication:
Estados Unidos