[Risk of hematogenous metastasis of cancer of the uterine cervix]. / Uber das Risiko der hämatogenen Fernmetastasierung beim Karzinom der Cervix uteri.

Metastasis development in cervical cancer was analysed retrospectively to determine whether haematogenic metastases occurred with higher frequency in younger women than in older women. Based on clinical and morphologic data, parameters for the identification of a high-risk group for the development of haematogenic metastases were established. The data of 533 patients who underwent therapy at the University Women's Hospital Berlin-Charlottenburg from 1970 to 1984 were evaluated. 11.8% of these patients developed haematogenic metastases. No significant difference was found in the 5-year risk for development of haematogenic metastases between different age groups. Furthermore, no increase in the incidence of haematogenic metastases was found in women under 35 years in the course of time. The influence of pretreatment characteristics for the development of haematogenic metastases was assessed in 185 patients who underwent surgery for cervical cancer from 1979 to 1984. Univariate as well as multivariate regression analysis of histopathologic characteristics in the surgical specimens revealed blood vessel invasion, tumour grading, dissociated tumour growth, and number of mitoses as important parameters for the occurrence of haematogenic metastases. In this study group, patient age strongly influenced the occurrence of haematogenic metastases. In contrast, prognostic parameters for the development of local recurrence of the disease were derived from morphologic data which described the locoregional spread of the tumour (staging, tumour growth beyond the cervix, involvement of the corpus uteri, and lymph node involvement).(ABSTRACT TRUNCATED AT 250 WORDS)