Palpebral syringomas and Down's syndrome.
Dermatology
; 189(3): 248-50, 1994.
Article
in En
| MEDLINE
| ID: mdl-7949476
ABSTRACT
BACKGROUND:
Palpebral syringomas have been reported to be more frequent in patients with Down's syndrome than in the normal population.OBJECTIVE:
The aim of the present study was to evaluate, in a population of institutionalized patients with Down's syndrome, the prevalence of syringomas and their possible cytogenetic relationships.METHODS:
Sixty-one institutionalized patients with Down's syndrome were examined in order to assess the presence of palpebral syringomas. Sixty mentally retarded non-Down's syndrome individuals were used to control group.RESULTS:
Fourteen patients, 13 females and 1 male, were found to be affected. The prevalence of syringomas in both sexes was 23%; 42% of all females, and 55% when only adult females were considered, had syringomas. Thirteen of the 14 affected patients had a karyotype of Down's syndrome with free trisomy 21, 1 had a mosaicism 47,XX, +21/46,XX. Histologic examination confirmed the diagnosis in all 4 biopsied cases. A clear-cell pattern was observed only in 1 patient while, sporadically, few tubules showed a central syringial-type cuticula.CONCLUSION:
The higher prevalence found in females, as compared to males, can be partially explained by their older age (mean 23.8 vs. 13.9 years). Palpebral syringomas are a common cutaneous pathology in adult females with Down's syndrome.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sweat Gland Neoplasms
/
Down Syndrome
/
Syringoma
/
Eyelid Neoplasms
Type of study:
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Child
/
Female
/
Humans
/
Male
Language:
En
Journal:
Dermatology
Journal subject:
DERMATOLOGIA
Year:
1994
Document type:
Article
Affiliation country:
Italia