Molecular cloning of an orphan transporter. A new member of the neurotransmitter transporter family.
FEBS Lett
; 357(1): 86-92, 1995 Jan 02.
Article
in En
| MEDLINE
| ID: mdl-8001687
ABSTRACT
A complementary DNA clone predicted to encode a novel transporter was isolated from rat brain and the localization of its mRNA was examined. The cDNA, designated rB21a, predicts a protein with 12 putative transmembrane domains that exhibits significant sequence homology with neurotransmitter transporters. Expression studies have not yet identified the endogenous substrate for this transporter, but the presence of rB21a mRNA within the leptomeninges of the brain suggests the transporter may regulate CSF levels of its substrate. The cloning of rB21a provides the means to determine its physiological functions and the potential to design novel, transporter-based therapeutic agents for neurological and psychiatric disorders.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Membrane Transport Proteins
/
Brain
/
Carrier Proteins
/
Neurotransmitter Agents
/
Nerve Tissue Proteins
Limits:
Animals
Language:
En
Journal:
FEBS Lett
Year:
1995
Document type:
Article