Bilateral injections of beta A(25-35) + IBO into the hippocampus disrupts acquisition of spatial learning in the rat.
Neuroreport
; 5(2): 165-8, 1993 Nov 18.
Article
in En
| MEDLINE
| ID: mdl-8111004
ABSTRACT
Focal deposits of beta-amyloid (beta A) in the hippocampus have been implicated in Alzheimer's disease. In this study we assessed the effects of bilateral injections into the hippocampus of beta A(25-35), a combination of beta A(25-35) with ibotenic acid (IBO), and IBO on spatial learning in the rat. Bilateral injections of beta A(25-35) into the hippocampus together with IBO (which by itself has no neurotoxic effects) produced a dramatic disruption in the acquisition of a spatial learning in the rat. Separate injections into the hippocampus of beta A(25-35) or the incubated form of beta A(25-35) alone failed to significantly affect maze acquisition in the rat. Histological examination revealed that only the combination of beta A(25-35) with IBO produced a lesion along with focal deposits in the hippocampus.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptide Fragments
/
Spatial Behavior
/
Amyloid beta-Peptides
/
Hippocampus
/
Ibotenic Acid
/
Learning Disabilities
/
Memory Disorders
Limits:
Animals
Language:
En
Journal:
Neuroreport
Journal subject:
NEUROLOGIA
Year:
1993
Document type:
Article