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Cerebrospinal fluid interleukin-6, prostaglandin E2 and autoantibodies in patients with neuropsychiatric systemic lupus erythematosus and central nervous system infections.
Tsai, C Y; Wu, T H; Tsai, S T; Chen, K H; Thajeb, P; Lin, W M; Yu, H S; Yu, C L.
Affiliation
  • Tsai CY; Department of Medicine, Veterans General Hospital-Taipei, National Yang-Ming Medical College, Taiwan, ROC.
Scand J Rheumatol ; 23(2): 57-63, 1994.
Article in En | MEDLINE | ID: mdl-8165438
ABSTRACT
Cerebrospinal fluid (CSF) from patients with a variety of central nervous system (CNS) disorders was assayed for cytokines, prostaglandins, and autoantibodies. CSF interleukin-6 (IL-6) in patients with CNS infection (374.24 +/- 92.61 pg/mL) and neuropsychiatric systemic lupus erythematosus (NP-SLE) (71.40 +/- 5.89 pg/mL) were significantly higher than in patients with CNS inflammation (33.92 +/- 29.36 pg/mL) or controls (non-inflammatory CNS diseases) (4.35 +/- 3.00 pg/mL). Interleukin-1 beta, interferon alpha, and tumor necrosis factor alpha were undetectable in these samples CSF prostaglandin E2 (PGE2) also exhibited similar patterns as IL-6. CSF immunoglobulin G (IgG) in patients with NP-SLE (8.84 +/- 1.80 mg/dL) was much higher than in patients with CNS infection (4.65 +/- 3.09 mg/dL), CNS inflammation (2.54 +/- 1.24 mg/dL), or controls (2.11 +/- 1.03 mg/dL). CSF autoantibodies against calf thymus antigens were present in patients with NP-SLE but not in patients with CNS infection as demonstrated by immunoblot. These results suggest that high IL-6 and PGE2 in CSF favors the diagnosis of CNS infection, while modestly elevated IL-6, high IgG, and autoantibodies against calf thymus antigens in CSF are the features of NP-SLE.
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Collection: 01-internacional Database: MEDLINE Main subject: Autoantibodies / Dinoprostone / Central Nervous System Diseases / Interleukin-6 / Lupus Erythematosus, Systemic Type of study: Diagnostic_studies / Etiology_studies Limits: Humans Language: En Journal: Scand J Rheumatol Year: 1994 Document type: Article
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Collection: 01-internacional Database: MEDLINE Main subject: Autoantibodies / Dinoprostone / Central Nervous System Diseases / Interleukin-6 / Lupus Erythematosus, Systemic Type of study: Diagnostic_studies / Etiology_studies Limits: Humans Language: En Journal: Scand J Rheumatol Year: 1994 Document type: Article