[The effect of cerebrocrast on erythrocyte function]. / Vliianie tserebrokrasta na funktsional'noe sostoianie éritrotsitov.
Eksp Klin Farmakol
; 56(3): 35-7, 1993.
Article
in Ru
| MEDLINE
| ID: mdl-8219988
ABSTRACT
The new calcium antagonist cerebrocrast intravenously infused in a dose of 0.4 micrograms.kg-1.min-1 during 15 min prevented erythrocyte deformability disturbances at the end of cerebral ischemia in rats, which was induced by carotid artery occlusion during 30 min. The agents also prevented the deformability 1 hour after the onset of recirculation. Cerebrocrast reduced spontaneous erythrocyte aggregation, the strength of erythrocytic aggregates, and hemoglobin affinity for oxygen. The latter effect was associated with the drug-induced increase in erythrocytic 2,3-diphosphoglycerate levels.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dihydropyridines
/
Calcium Channel Blockers
/
Erythrocytes
Limits:
Animals
Language:
Ru
Journal:
Eksp Klin Farmakol
Journal subject:
FARMACOLOGIA
Year:
1993
Document type:
Article