Demineralized bone matrix. Enhancement of spinal fusion.
Spine (Phila Pa 1976)
; 18(12): 1634-9, 1993 Sep 15.
Article
in En
| MEDLINE
| ID: mdl-8235843
ABSTRACT
A study was conducted to determine the ability of demineralized bone matrix gel to act as an osteoconductive/osteoinductive material to enhance canine spinal fusion. Seven dogs underwent posterior spinal fusion. Four-level fusions were performed with one of four procedures at each level decortication alone, with gel added, with autograft, or with both gel and autograft. Dogs were killed at 6 weeks and early histologic response was studied. At untreated control sites, little bone formation was evident. Gel-filled sites showed abundant osteoid, with 60% of demineralized particles fused to or surrounded by new bone. Sites filled with autograft had more new bone, but there was more osteoid at gel-treated sites. Autograft augmented with gel showed the most vigorous response, with extensive bridging between demineralized particles, host bone, autograft, and new bone. Significantly less autograft was needed to induce a similar amount of new bone formation when gel was added. Use of the gel as an autograft extender may improve the chance for successful spinal fusion.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Spinal Fusion
/
Bone Matrix
/
Calcification, Physiologic
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
En
Journal:
Spine (Phila Pa 1976)
Year:
1993
Document type:
Article