Enteric vascular endothelial response to bacterial endotoxin.
Int J Exp Pathol
; 74(6): 593-601, 1993 Dec.
Article
in En
| MEDLINE
| ID: mdl-8292557
ABSTRACT
The response of enteric vasculature to endotoxin was examined at the ultrastructural level using a murine model of endotoxin-induced acute diarrhoea. Morphological changes indicative of endothelial damage were evident as early as 15 minutes following endotoxin challenge. These changes, characterized by widening of intercellular spaces, increased microvillous projections and the appearance of stress fibres, preceded the leucocytic response. Endothelial damage increased with time, being associated with progressive degenerative changes in the plasma membrane, cytoplasm and organelles, ultimately leading to desquamation. These latter changes were temporally associated with margination of neutrophils and platelet adhesion to the denuded subendothelium. The venules were the primary site of these changes while the capillaries were the least affected. The arterioles were markedly constricted with minimal endothelial damage. These changes suggest that the enteric vascular endothelium may be an important target organ, and the resultant endothelial injury may have implications in host responses to endotoxin.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Endothelium, Vascular
/
Diarrhea
/
Endotoxins
/
Intestinal Mucosa
Type of study:
Etiology_studies
Limits:
Animals
Language:
En
Journal:
Int J Exp Pathol
Journal subject:
PATOLOGIA
Year:
1993
Document type:
Article
Affiliation country:
India