Effects of hormone therapy on the endometrium.
Mod Pathol
; 6(1): 94-106, 1993 Jan.
Article
in En
| MEDLINE
| ID: mdl-8426860
ABSTRACT
PIP: Steroid sex hormones cause immediate changes in the endometrium. The histologic effect depends on the hormone, the potency, dosage, and the host receptor status. Oral contraceptives (OCs) containing a low-dose, low-potency progesterone and low-dose estrogen stop proliferation of the glands during the 1st few cycles and the glands are straight and unevenly distributed, with considerable stroma between them. The minimal secretory features of the glands disappear with longterm use of these OCs, resulting in complete atrophy of the glands and of the stroma. These OCs also cause decidual reaction without spiral arterioles and stromal granulocytes. OCs with high potency progesterone cause distinct hyperplasia of the endometrial stroma and vessels, atrophy of the glands, and stromal myomatous nodules. Ovulation induction therapy consists of various combinations of some drugs (clomid, human menopausal gonadotropins, gonadotropin-releasing hormone, and human chorionic gonadotropin). This therapy accelerates secretory changes in the stroma, resulting in enhancement of the endometrial maturation process. It makes it difficult to differentiate between glands displaying early secretory changes and an edematous, decidualized stroma. Hormone replacement therapy using estrogens and progesterone cause different histologic patterns, including stromal hyperplasia and decidual transformation, glandular and adenomatous hyperplasia, glandular metaplasia, proliferative and secretory endometrium, atrophic endometrium, and any of these with endometrial atrophy. Progesterone therapy for endometrial hyperplasia and neoplasia produces secretory changes of the endometrium, such as subnuclear vacuole, decidual reaction, and squamoid "morules." These changes can result in residual carcinoma. Tamoxifen therapy for breast cancer is linked with endometrial hyperplasia, polyps, adenomyosis, adenomatous hyperplasia, and adenocarcinoma.
Key words
Biology; Breast Cancer; Cancer; Clinical Research; Contraception; Contraceptive Methods--side effects; Cytologic Effects; Decidual Cell Reaction; Diseases; Endocrine System; Endometrium; Family Planning; Fertility Agents; Fertilization; Genitalia; Genitalia, Female; Histology; Hormones--side effects; In Vitro; Literature Review; Menopause; Neoplasms; Oral Contraceptives--side effects; Ovulation; Physiology; Progestational Hormones; Progesterone--side effects; Reproduction; Reproductive Control Agents; Research Methodology; Tamoxifen--side effects; Treatment; Urogenital System; Uterus
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovulation Induction
/
Progesterone
/
Tamoxifen
/
Estrogen Replacement Therapy
/
Contraceptives, Oral
/
Endometrium
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Mod Pathol
Journal subject:
PATOLOGIA
Year:
1993
Document type:
Article
Country of publication:
Estados Unidos