Autoimmune hepatitis and hypothyroidism associated with anti-thyroid hormone autoantibodies.
Intern Med
; 32(1): 21-5, 1993 Jan.
Article
in En
| MEDLINE
| ID: mdl-8495039
ABSTRACT
A 40-year-old hypothyroid female who had been treated with synthetic thyroxine was admitted to our hospital in October 1988 due to abnormal liver function tests. She had low serum free triiodothyronine (T3; 2.3 pg/ml) and high serum thyrotropin (TSH; 20.8 microU/ml) concentrations. On the other hand, the serum free thyroxine (FT4) level was inappropriately high, being 2.46 ng/dl. Immune precipitation of radiolabeled thyroid hormones with her serum disclosed the binding of 125I-T3 and 125I-T4 to the extent of 9.5% and 11.3%, respectively (normal ranges for 125I-T3 and 125I-T4 binding are less than 6.3% and 5.9%, respectively). 125I-T4 binding to the patient's serum gamma globulin was completely displaced with the addition of unlabeled T4. Further examination disclosed that anti-T4 antibodies in her serum belong to IgG kappa class immunoglobulin.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autoimmune Diseases
/
Hepatitis
/
Hypothyroidism
Type of study:
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
Intern Med
Journal subject:
MEDICINA INTERNA
Year:
1993
Document type:
Article
Affiliation country:
Japón