Different gonadotropin and leuprorelin ovulation induction regimens markedly affect follicular fluid hormone levels and folliculogenesis.
Fertil Steril
; 65(2): 387-93, 1996 Feb.
Article
in En
| MEDLINE
| ID: mdl-8566268
ABSTRACT
OBJECTIVES:
To clarify the endocrine mechanisms underlying the outcome of different ovulation induction regimens with gonadotropins and GnRH agonists (GnRH-a).DESIGN:
Prospective study.SETTING:
Reproductive Endocrinology Center, University of Bologna. PATIENTS Forty eumenorrheic women randomly assigned to four groups of 10 subjects each.INTERVENTIONS:
Ovulation induction regimens group A, purified FSH only; group B, purified FSH and flare-up GnRH-a; group C, purified FSH and long GnRH-a; and group D, hMG and long GnRH-a. MAIN OUTCOMEMEASURES:
Pelvic ultrasound and hormone levels in daily serum samples and in follicular fluid drawn immediately before hCG administration.RESULTS:
Exogenous gonadotropin dose did not differ among groups. Group B had fewer preovulatory follicles than group C. Group B had higher serum LH, FSH, E2, P, T, and follicular fluid LH, E2, T, and alpha-inhibin than groups C and/or D. Groups C and D did not differ.CONCLUSIONS:
Long GnRH-a regimens improved follicle yield and the endocrine milieu in spite of comparable exogenous gonadotropin dose and lower serum FSH and thus appear to be preferable in assisted reproduction. Reduced folliculogenesis found in flare-up GnRH-a regimens could be mediated by the atretic effects of high intraovarian androgens. Efficacy of purified FSH and hMG was comparable.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovulation Induction
/
Gonadal Steroid Hormones
/
Follicular Fluid
/
Leuprolide
/
Fertility Agents, Female
/
Follicle Stimulating Hormone
/
Ovarian Follicle
/
Menotropins
Type of study:
Clinical_trials
/
Observational_studies
Limits:
Adult
/
Female
/
Humans
Language:
En
Journal:
Fertil Steril
Year:
1996
Document type:
Article
Affiliation country:
Italia