Concentration-effect relationships of eltanolone given as a bolus dose or constant rate intravenous infusion to healthy male volunteers.
Anesthesiology
; 84(6): 1317-26, 1996 Jun.
Article
in En
| MEDLINE
| ID: mdl-8669672
ABSTRACT
BACKGROUND:
The primary purpose of this study was to evaluate concentration-effect relationships of the new steroid anesthetic eltanolone during recovery from a bolus dose and constant rate intravenous infusion in healthy male volunteers.METHODS:
Ten subjects received a bolus dose of 0.75 mg/kg eltanolone over 20 s. A 2-h constant rate intravenous infusion of eltanolone was given to five subjects at a rate of 2 mg.kg-1.h-1 and to another five subjects at a rate of 3.5 mg.kg-1.h-1. Recovery performance was assessed as the time required to reach different end-points and by means of three different psychomotor tests.RESULTS:
A low interindividual variability was found in the serum concentration of eltanolone at the pharmacodynamic end-points during recovery. The Cp50 value for "eye opening" was 382 micrograms/L (95% confidence interval, 285-489) after a bolus dose corresponding to a median time of 16 min (range 8-25). After eltanolone infusion, the Cp50 value for "eye opening" was 507 micrograms/L (95% confidence interval, 425-605) and the corresponding median time was 21 min (range 8-25) in the low-dose group and 49 min (range 31-66) in the high-dose group. The Cp50 values at the same effect end-points in the bolus group were less than those in the infusion groups, probably because of insufficient equilibration time between serum and the effect compartment.CONCLUSIONS:
Recovery characteristics of eltanolone were predictable because of a relatively low interindividual variability in serum concentrations but with a slow bloodeffect compartment equilibration.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnanolone
/
Anesthetics
Type of study:
Prognostic_studies
Limits:
Adolescent
/
Adult
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Anesthesiology
Year:
1996
Document type:
Article
Affiliation country:
Suecia