Inhibition of aldose reductase by dihydroflavonols in Engelhardtia chrysolepis and effects on other enzymes.
Experientia
; 52(6): 564-7, 1996 Jun 15.
Article
in En
| MEDLINE
| ID: mdl-8698090
ABSTRACT
Astilbin and neoastilbin, dihydroflavonol rhamnosides from Engelhardtia chrysolepis, showed potent inhibition of lens aldose reductase. Kinetic analysis showed astilbin exhibited uncompetitive inhibition against both dl-glyceraldehyde and NADPH. These taxifolin glycosides were selective inhibitors of aldose reductase with no inhibition of NADH oxidase.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plants
/
Flavonoids
/
Aldehyde Reductase
/
Flavonols
/
Enzyme Inhibitors
/
Kidney
/
Lens, Crystalline
Limits:
Animals
Language:
En
Journal:
Experientia
Year:
1996
Document type:
Article
Affiliation country:
Japón