Serum, fecal, and breast milk rotavirus antibodies as indices of infection in mother-infant pairs.
J Infect Dis
; 174 Suppl 1: S22-9, 1996 Sep.
Article
in En
| MEDLINE
| ID: mdl-8752287
Sixty-eight mother-infant pairs were followed for 12-17 months after birth. Rotavirus infections in children were detected by EIA of weekly fecal antigen and anti-rotavirus IgA levels, by EIA of anti-rotavirus IgG in sera at birth, 6, or 12-17 months of age, and by anti-rotavirus EIA IgA and neutralizing antibody (NA) in monthly samples of maternal breast milk. Primary rotavirus infection was detected in 26 children (in 15 [58%] by fecal excretion, 12 [46%] by IgG seroconversion, and 22 [85%] by elevations of IgA anti-rotavirus antibodies [IgA coproconversion] in consecutive fecal specimens). Rotavirus "challenge" was detected by rises in levels of NA in breast milk in 9 (47%) of 19 mothers, including 5 (26%) from pairs in which there was no other evidence of rotavirus infection. Reinfections were detected in 2 children by rotavirus excretion and in 4 by coproconversion. IgA coproconversion is the most sensitive technique for detection of symptomatic and asymptomatic rotavirus infection in young children.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rotavirus Infections
/
Rotavirus
/
Feces
/
Milk, Human
/
Antibodies, Viral
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Animals
/
Female
/
Humans
/
Infant
/
Male
/
Newborn
Country/Region as subject:
Oceania
Language:
En
Journal:
J Infect Dis
Year:
1996
Document type:
Article
Affiliation country:
Australia
Country of publication:
Estados Unidos