An adoption study of DSM-IIIR alcohol and drug dependence severity.
Drug Alcohol Depend
; 41(1): 9-15, 1996 May.
Article
in En
| MEDLINE
| ID: mdl-8793305
ABSTRACT
OBJECTIVE:
The objective of this study was to evaluate the role of genetic factors in alcohol and drug dependence at various levels of DSM-IIIR psychoactive substance dependence severity.METHOD:
One-hundred-and-ninety-seven adoptees (95 case adoptees with biological parental alcoholism, drug dependence or antisocial personality disorder and 102 control adoptees) were interviewed for the presence of alcohol abuse or dependence and drug abuse or dependence using the Diagnostic Interview Schedule-DIS IIIR.RESULTS:
Adoptees with five or more DSM-IIIR criteria for alcohol dependence demonstrated evidence of a genetic effect using this adoption paradigm (odds ratio = 2.3, 95% C.I. (1.1, 4.9)). Adoptees with one or more DSM-IIIR criteria for drug dependence demonstrated a genetic effect (odds ratio = 2.4, 95% C.I. (1.3, 4.4).CONCLUSIONS:
This study suggests genetic factors influence the risk for alcohol and drug dependence at different thresholds of severity as determined by DSM-IIIR symptom severity count.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Psychiatric Status Rating Scales
/
Psychotropic Drugs
/
Adoption
/
Illicit Drugs
/
Substance-Related Disorders
/
Alcoholism
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Drug Alcohol Depend
Year:
1996
Document type:
Article
Affiliation country:
Estados Unidos