Tryptophan depletion in obsessive-compulsive patients.
Biol Psychiatry
; 40(5): 398-402, 1996 Sep 01.
Article
in En
| MEDLINE
| ID: mdl-8874841
ABSTRACT
Twelve patients with obsessive-compulsive disorder were studied after the administration of a mixture of amino acids devoid of tryptophan (TRP) or a mixture containing all the essential amino acids, in a double-blind, crossover design. The TRP-free mixture caused a marked depletion of plasma TRP. After TRP decrease, mean ratings of obsessions and compulsions, measured by Visual Analogue Scales (VAS) ratings, did not worsen. In contrast with other reports in literature, TRP depletion also failed to alter mood in our subjects.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tryptophan
/
Obsessive-Compulsive Disorder
Type of study:
Clinical_trials
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Biol Psychiatry
Year:
1996
Document type:
Article
Affiliation country:
Italia