Identification of a family of Rab G-proteins in Plasmodium falciparum and a detailed characterisation of pfrab6.
Mol Biochem Parasitol
; 80(1): 77-88, 1996 Sep.
Article
in En
| MEDLINE
| ID: mdl-8885224
ABSTRACT
As a first step towards developing a set of compartment-specific probes for studying protein trafficking in the malaria-infected erythrocyte, we describe here a family of Plasmodium falciparum Rab proteins. We characterise in detail P. falciparum Rab6 (PfRab6) a marker which in other cells is specific for the Golgi/trans Golgi network. Although PfRab6 mRNA is expressed throughout the intraerythrocytic cycle, maximal expression occurs at the trophozoite stage. Immunofluorescence microscopy shows that the distribution of PfRab6 changes during the final stages of parasite maturation, coalescing into multiple foci, each of which is associated with the nucleus of a forming daughter parasite.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plasmodium falciparum
/
Carrier Proteins
/
Genes, Protozoan
/
Ras Proteins
/
Rab GTP-Binding Proteins
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
En
Journal:
Mol Biochem Parasitol
Year:
1996
Document type:
Article
Affiliation country:
Francia