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Antiandrogen. IV. C-17 spiro 2-oxasteroids.
Koizumi, N; Takegawa, S; Mieda, M; Shibata, K.
Affiliation
  • Koizumi N; Research Department, Teikoku Hormone Mfg. Co., Ltd., Kawasaki, Japan.
Chem Pharm Bull (Tokyo) ; 44(11): 2162-4, 1996 Nov.
Article in En | MEDLINE | ID: mdl-8945781
ABSTRACT
The preparation of 6- and/or 7-substituted 3-oxo-2-oxasteroids having a spirotetrahydrofuran ring at the 17-position is described. These compounds showed high antiandrogenic potency in the castrated male rat.
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Collection: 01-internacional Database: MEDLINE Main subject: Steroids / Androgen Antagonists Limits: Animals Language: En Journal: Chem Pharm Bull (Tokyo) Year: 1996 Document type: Article Affiliation country: Japón
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Collection: 01-internacional Database: MEDLINE Main subject: Steroids / Androgen Antagonists Limits: Animals Language: En Journal: Chem Pharm Bull (Tokyo) Year: 1996 Document type: Article Affiliation country: Japón