Functional role of nitric oxide in guinea pig tracheal epithelium.
Life Sci
; 56(13): PL231-5, 1995 Feb 17.
Article
in En
| MEDLINE
| ID: mdl-9001450
Nitric oxide (NO) may play an important regulatory role in airway function. We have, thus, investigated in vitro whether epithelium derived NO may modulate cholinergic neurotransmission, via release of NO in guinea pig trachea, by using L-arginine (L-ARG), a precursor of NO synthesis, and L-N(G)-nitro-arginine-methyl-ester (L-NAME), an inhibitor of NO synthase. Results show that L-ARG and L-NAME modify acetylcholine sensitivity in epithelium-intact smooth muscle preparations, suggesting a probable NO synthesis by tracheal guinea pig epithelium.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Trachea
/
Nitric Oxide
Limits:
Animals
Language:
En
Journal:
Life Sci
Year:
1995
Document type:
Article
Affiliation country:
Italia
Country of publication:
Países Bajos