New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities.
J Antibiot (Tokyo)
; 49(12): 1196-203, 1996 Dec.
Article
in En
| MEDLINE
| ID: mdl-9031664
ABSTRACT
New antitumor substances, FR901463, FR901464 and FR901465 were isolated from the culture broth of a bacterium of Pseudomonas sp. No.2663. FR901463, FR901464 and FR901465 remarkably enhanced the transcriptional activity of the promoter of SV40 DNA virus. Further, these compounds exhibited potent antitumor activities against murine and human tumor cell lines in vitro.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pseudomonas
/
Antibiotics, Antineoplastic
Limits:
Animals
/
Female
/
Humans
Language:
En
Journal:
J Antibiot (Tokyo)
Year:
1996
Document type:
Article
Affiliation country:
Japón
