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Clinical features of patients with chronic liver disease associated with hepatitis C virus genotype 1a/I in Okinawa, Japan.
Sakugawa, H; Nakasone, H; Kinjo, F; Saito, A; Keida, Y; Kikuchi, K; Oyadomari, Y; Ishihara, M; Nakasone, K; Yogi, S; Kinjo, Y; Taira, M.
Affiliation
  • Sakugawa H; First Department of Internal Medicine, Faculty of Medicine, School of Medicine, University of the Ryukyus, Okinawa, Japan.
J Gastroenterol Hepatol ; 12(2): 176-81, 1997 Feb.
Article in En | MEDLINE | ID: mdl-9083921
ABSTRACT
The clinical characteristics of chronic hepatitis C virus (HCV) carriers with HCV genotype 1a/I infection were investigated and compared with those of chronic HCV carriers infected with 1b/II, 2a/III, 2b/IV and the mixed type of infection. We found that 16 of 408 (3.9%) carriers had HCV genotype 1a infection, comprising four of 67 (6.0%) blood donors, 11 of 263 (4.2%) patients with chronic hepatitis and one of 39 (2.6%) patients with liver cirrhosis. Three of 408 subjects had a mixed infection of genotypes 1a/I and 1b/II. All carriers with genotype 1a (including those with the mixed infection) were of Japanese origin and all, except one who was born in Brazil, were born in Okinawa Prefecture. Nine of 14 patients infected with genotype 1a for whom medical records were obtained had a history suggestive of infection through blood exposure; six had had blood transfusions, one had tattoos, one is a nurse and one had a history of drug addiction. There were no haemophiliacs or other multitransfused patients in the genotype 1a group. Of 10 patients infected with genotype 1a who received interferon (IFN) therapy, four (40%) showed a complete response. Although the small number of patients infected with genotype 1a in the present study precluded statistical analysis of the response to IFN, the response in patients with genotype 1a was better than the response in those infected with genotype 1b and poorer than the response in those patients infected with genotype 2a/III or 2b/IV.
Subject(s)
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Collection: 01-internacional Database: MEDLINE Main subject: Hepatitis C Type of study: Prevalence_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: J Gastroenterol Hepatol Journal subject: GASTROENTEROLOGIA Year: 1997 Document type: Article Affiliation country: Japón
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Collection: 01-internacional Database: MEDLINE Main subject: Hepatitis C Type of study: Prevalence_studies / Risk_factors_studies Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: En Journal: J Gastroenterol Hepatol Journal subject: GASTROENTEROLOGIA Year: 1997 Document type: Article Affiliation country: Japón
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