Kinetic analysis of rubidium and thallium as deposited myocardial blood flow tracers in isolated rabbit heart.
Am J Physiol
; 272(3 Pt 2): H1480-90, 1997 Mar.
Article
in En
| MEDLINE
| ID: mdl-9087627
ABSTRACT
Evaluation of myocardial perfusion with tracers such as thallium and rubidium is based on the assumption that tissue tracer content is proportional to flow. The purpose of this study was to evaluate the relationship between flow and tissue tracer content of 201Tl and 83Rb in the isolated perfused rabbit heart. 83Rb (86-day half-life), an isotope that is not used clinically, was used as a subsitute for 82Rb (76-s half-life) to improve the accuracy and precision of data acquisition. The multiple indicator-dilution technique was employed with two independent computational approaches. The first approach explicitly deconvolved 201Tl and 83Rb venous concentration curves by the intravascular reference tracer curve. The second approach used a conventional analysis. Both approaches showed that there was more early washout of 83Rb than 201Tl and that the heart retained 201Tl better than 83Rb within 2 min after isotope introduction. These data indicate that 201Tl is a better perfusion tracer than 83Rb in the isolated rabbit heart.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rubidium Radioisotopes
/
Thallium Radioisotopes
/
Coronary Circulation
/
Heart
/
Myocardium
Type of study:
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Am J Physiol
Year:
1997
Document type:
Article
Affiliation country:
Estados Unidos