Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Cell
; 89(2): 309-19, 1997 Apr 18.
Article
in En
| MEDLINE
| ID: mdl-9108485
ABSTRACT
A novel secreted glycoprotein that regulates bone resorption has been identified. The protein, termed Osteoprotegerin (OPG), is a novel member of the TNF receptor superfamily. In vivo, hepatic expression of OPG in transgenic mice results in a profound yet nonlethal osteopetrosis, coincident with a decrease in later stages of osteoclast differentiation. These same effects are observed upon administration of recombinant OPG into normal mice. In vitro, osteoclast differentiation from precursor cells is blocked in a dose-dependent manner by recombinant OPG. Furthermore, OPG blocks ovariectomy-associated bone loss in rats. These data show that OPG can act as a soluble factor in the regulation of bone mass and imply a utility for OPG in the treatment of osteoporosis associated with increased osteoclast activity.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteoclasts
/
Osteopetrosis
/
Glycoproteins
/
Bone Density
/
Receptors, Cytoplasmic and Nuclear
Type of study:
Prognostic_studies
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
En
Journal:
Cell
Year:
1997
Document type:
Article
Affiliation country:
Estados Unidos