Inhibition of aldose reductase and sorbitol accumulation by astilbin and taxifolin dihydroflavonols in Engelhardtia chrysolepis.
Biosci Biotechnol Biochem
; 61(4): 651-4, 1997 Apr.
Article
in En
| MEDLINE
| ID: mdl-9145524
ABSTRACT
Dihydroflavonol taxifolin and its glycoside, astilbin, from Engelhardtia chrysolepis inhibited rat lens and recombinant human aldose reductase. Taxifolin also inhibited sorbitol accumulation in human red blood cells. Furthermore, this dihydroflavonol aglycone maintained the clarity of rat lens incubated with a high concentration of glucose. These dihydroflavonols may be effective for preventing osmotic stress in hyperglycemia.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quercetin
/
Sorbitol
/
Trees
/
Flavonoids
/
Aldehyde Reductase
Limits:
Animals
/
Humans
Language:
En
Journal:
Biosci Biotechnol Biochem
Journal subject:
BIOQUIMICA
/
BIOTECNOLOGIA
Year:
1997
Document type:
Article
Affiliation country:
Japón