Human immunodeficiency virus infection is a major risk factor for detection of human papillomavirus DNA in esophageal brushings.
Clin Infect Dis
; 24(4): 565-9, 1997 Apr.
Article
in En
| MEDLINE
| ID: mdl-9145728
ABSTRACT
The presence of human papillomavirus (HPV) DNA in esophageal brushings from human immunodeficiency virus (HIV)-seropositive hosts was investigated in a cross-sectional study. Oral and esophageal brushings from individuals scheduled for esophagogastroscopy (53 HIV-positive and 61 age-matched HIV-negative patients) were tested for the presence of HPV DNA by a consensus L1 polymerase chain reaction assay. HPV DNA was detected in esophageal brushings of 9 (17%) of the 53 HIV-seropositive patients and 0 of the 61 HIV-negative individuals. HPV-16 DNA was the most frequently detected. No proliferative mucosal lesion was noted in individuals with HPV-positive esophageal brushings. Cytological smears were done for 6 of the 9 patients with HPV-positive esophageal brushings, and epithelial atypia was recorded for 1. HIV infection and a history of genital herpes were strong independent predictors of HPV, suggesting that HPV is transmitted sexually in the esophagus.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Papillomaviridae
/
Tumor Virus Infections
/
AIDS-Related Opportunistic Infections
/
Papillomavirus Infections
/
Capsid Proteins
/
Esophagus
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
Language:
En
Journal:
Clin Infect Dis
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
1997
Document type:
Article
Affiliation country:
Canadá