Determination of the parent of origin in nine cases of prenatally detected chromosome aberrations found after intracytoplasmic sperm injection.
Hum Reprod
; 12(4): 682-6, 1997 Apr.
Article
in En
| MEDLINE
| ID: mdl-9159424
ABSTRACT
Prenatal cytogenetic analysis of 71 fetuses conceived by intracytoplasmic sperm injection (ICSI) resulted in the detection of nine (12.7%) chromosome aberrations including two cases of 47,XXY, four cases involving a 45,X cell line and three autosomal trisomies. Molecular analysis of the parental origin of the deleted or supernumerary chromosome was performed by using polymorphic microsatellite markers. Six cases involving a sex chromosome abnormality were found to be of paternal origin while the two trisomic cases that could be analysed were of maternal origin. Two cases involved the same infertile couple who had two consecutive ICSI pregnancies terminated because of a chromosome abnormality. The replaced embryos in both cases originated from a single batch of ICSI fertilized oocytes of which part was used to initiate the first pregnancy and part was cryopreserved and used to initiate the second pregnancy.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parents
/
Prenatal Diagnosis
/
Sperm-Ovum Interactions
/
Fertilization in Vitro
/
Chromosome Aberrations
Type of study:
Diagnostic_studies
Limits:
Female
/
Humans
/
Male
/
Pregnancy
Language:
En
Journal:
Hum Reprod
Journal subject:
MEDICINA REPRODUTIVA
Year:
1997
Document type:
Article
Affiliation country:
Países Bajos