A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA.
Nat Genet
; 16(2): 144-53, 1997 Jun.
Article
in En
| MEDLINE
| ID: mdl-9171825
ABSTRACT
We recently described a human marker chromosome containing a functional neo-centromere that binds anti-centromere antibodies, but is devoid of centromeric alpha-satellite repeats and derived from a hitherto non-centromeric region of chromosome 10q25. Chromosome walking using cloned single-copy DNA from this region enabled us to identify the antibody-binding domain of this centromere. Extensive restriction mapping indicates that this domain has an identical genomic organization to the corresponding normal chromosomal region, suggesting a mechanism for the origin of this centromere through the activation of a latent centromere that exists within 10q25.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromosomes, Human, Pair 10
/
DNA, Satellite
/
Centromere
Limits:
Humans
Language:
En
Journal:
Nat Genet
Journal subject:
GENETICA MEDICA
Year:
1997
Document type:
Article
Affiliation country:
Australia