Transforming growth factor-beta 3 mediated modulation of cell cycling and attenuation of 5-fluorouracil induced oral mucositis.
Oral Oncol
; 33(1): 47-54, 1997 Jan.
Article
in En
| MEDLINE
| ID: mdl-9192553
ABSTRACT
Mucositis is a common, dose-limiting complication in patients receiving cancer chemotherapy, which derives from damage to the epithelial cell layer. We have shown that transforming growth factor-beta 3 (TGF-beta 3) negatively regulates epithelial cell proliferation and reduces the incidence of oral mucositis. Here, we report the findings of a large study examining the effects of TGF-beta 3 administration in a hamster model on oral epithelial cell cycling in vivo, on oral mucositis, on weight retention and on survival. Topical application of TGF-beta 3 to the buccal mucosa significantly reduced basal cell proliferation, as measured by proliferating cell nuclear antigen (PCNA) immunohistochemistry and DNA ploidy. Administration of topical TGF-beta 3 prior to chemotherapy with 5-fluorouracil (5-FU) significantly reduced the severity of mucositis with respect to time, reduced chemotherapy-associated weight loss and increased survival.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stomatitis
/
Transforming Growth Factor beta
/
Fluorouracil
/
Antimetabolites, Antineoplastic
Limits:
Animals
Language:
En
Journal:
Oral Oncol
Journal subject:
NEOPLASIAS
Year:
1997
Document type:
Article
Affiliation country:
Estados Unidos