Folded structures in protonated reduced dipeptides.
J Pept Sci
; 2(6): 381-91, 1996.
Article
in En
| MEDLINE
| ID: mdl-9230466
ABSTRACT
Reduced dipeptides with the general formula RCO-Xaa-rXbb-N+HR'R" (rXbb, reduced analogue of residue Xbb NH-C alpha HR1-CrH2) are shown to adopt a folded conformation in solution and in the solid state. The protonated reduced amide bond is an active proton donor capable of interacting with a peptide carbonyl to give a strong hydrogen bond topologically equivalent to the i+2 or i+3-->i interaction. The resulting conformation is similar to the y- or beta-turn structure found in peptides and proteins.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Protons
/
Protein Folding
/
Dipeptides
Language:
En
Journal:
J Pept Sci
Journal subject:
BIOQUIMICA
Year:
1996
Document type:
Article
Affiliation country:
Francia