Robertsonian translocations in Paget's disease of bone.
J Orthop Res
; 15(3): 477-81, 1997 May.
Article
in En
| MEDLINE
| ID: mdl-9246098
ABSTRACT
The karyotypes of 14 patients with Paget's disease of bone were studied. The patients were recruited from our bone metabolism clinic where they received specific therapy for their skeletal disease. Eight of the 14 patients had chromosomal translocations localized to the D and G groups. None of the patients were related to one another, nor had any had the same lifelong environment. Thus, 57% of a sample of active patients with Paget's disease had Robertsonian translocations. By comparison, an age and sex-matched group of eight controls and 13 patients with osteoporosis who had been treated with bisphosphonates demonstrated no Robertsonian translocations. The prevalence of Robertsonian translocations in 14,000 newborns was reported to be 0.1%. These data suggest that a factor from the environment introduced during the lifetime of the patient could be present and could, in addition to genetic factors, affect gene replication during the development of Paget's disease.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteitis Deformans
/
Translocation, Genetic
/
Chromosomes, Human, Pair 13
/
Chromosomes, Human, Pair 14
/
Chromosomes, Human, Pair 15
Type of study:
Risk_factors_studies
Limits:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Orthop Res
Year:
1997
Document type:
Article
Affiliation country:
Estados Unidos