Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits.

MacPherson, L J; Bayburt, E K; Capparelli, M P; Carroll, B J; Goldstein, R; Justice, M R; Zhu, L; Hu, S; Melton, R A; Fryer, L; Goldberg, R L; Doughty, J R; Spirito, S; Blancuzzi, V; Wilson, D; O'Byrne, E M; Ganu, V; Parker, D T

MacPherson, L J; Bayburt, E K; Capparelli, M P; Carroll, B J; Goldstein, R; Justice, M R; Zhu, L; Hu, S; Melton, R A; Fryer, L; Goldberg, R L; Doughty, J R; Spirito, S; Blancuzzi, V; Wilson, D; O'Byrne, E M; Ganu, V; Parker, D T.

Affiliation

MacPherson LJ; Research Department, Novartis Pharmaceuticals, Summit, New Jersey 07901, USA.

J Med Chem ; 40(16): 2525-32, 1997 Aug 01.

Article in En | MEDLINE | ID: mdl-9258358

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Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Pyrazines / Cartilage / Matrix Metalloproteinase Inhibitors / Hydroxamic Acids Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1997 Document type: Article Affiliation country: Estados Unidos Country of publication: Estados Unidos

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