Stabilization of Xist RNA mediates initiation of X chromosome inactivation.
Cell
; 91(1): 99-107, 1997 Oct 03.
Article
in En
| MEDLINE
| ID: mdl-9335338
ABSTRACT
The onset of X inactivation is preceded by a marked increase in the level of Xist RNA. Here we demonstrate that increased stability of Xist RNA is the primary determinant of developmental up-regulation. Unstable transcript is produced by both alleles in XX ES cells and in XX embryos prior to the onset of random X inactivation. Following differentiation, transcription of unstable RNA from the active X chromosome allele continues for a period following stabilization and accumulation of transcript on the inactive X allele. We discuss the implications of these findings in terms of models for the initiation of random and imprinted X inactivation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transcription Factors
/
RNA, Messenger
/
Dosage Compensation, Genetic
/
RNA, Untranslated
Limits:
Animals
Language:
En
Journal:
Cell
Year:
1997
Document type:
Article
Affiliation country:
Reino Unido