Indomethacin in the management of elevated intracranial pressure: a review.
J Neurotrauma
; 14(9): 637-50, 1997 Sep.
Article
in En
| MEDLINE
| ID: mdl-9337126
ABSTRACT
Elevated intracranial pressure occurs frequently in patients with severe head injury. A number of studies in recent years suggest that indomethacin may be useful in the management of elevated intracranial pressure. Indomethacin acts primarily by reducing cerebral blood flow and decreasing cerebral edema following head injury. This review summarizes the basic and clinical studies of the effects of indomethacin on cerebral blood flow, brain edema, and intracranial pressure. The pharmacology of indomethacin, and issues for future investigation in the use of indomethacin in severe head injury, are discussed.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Brain Edema
/
Intracranial Pressure
/
Cerebrovascular Circulation
/
Indomethacin
/
Cyclooxygenase Inhibitors
/
Craniocerebral Trauma
Limits:
Animals
/
Humans
Language:
En
Journal:
J Neurotrauma
Journal subject:
NEUROLOGIA
/
TRAUMATOLOGIA
Year:
1997
Document type:
Article
Affiliation country:
Estados Unidos