Global dimensional complexity of multichannel EEG in mild Alzheimer's disease and age-matched cohorts.
Dement Geriatr Cogn Disord
; 8(6): 343-7, 1997.
Article
in En
| MEDLINE
| ID: mdl-9370086
ABSTRACT
Multichannel EEG as sequence of momentary brain field maps constitutes a trajectory through K-dimensional state space (K = number of channels); the complexity of this trajectory is assessed by the nonlinear measure of global correlation dimension (Global Dimensional Complexity, GDC) with the number of electrodes as embedding dimension. We analyzed eyes-closed EEG of three age-matched subject groups mild Alzheimer's disease (AD; n = 21), mild cognitive impairment (29) and subjective memory complaint (29). Kruskal-Wallis statistics showed an overall effect between groups. AD patients differed significantly (GDC = 4.56) from mild cognitive impairments (GDC = 4.98) and from subjective memory complaints (GDC = 4.93). GDC also had significant positive correlations with mental condition and performance (MMSE and WAIS-R scores). Thus, the dynamics of brain state development over time in mild AD differs from that in mild cognitive impairment and in subjective memory complaint cases.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Electroencephalography
/
Alzheimer Disease
Type of study:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Dement Geriatr Cogn Disord
Journal subject:
GERIATRIA
/
NEUROLOGIA
/
PSIQUIATRIA
Year:
1997
Document type:
Article
Affiliation country:
Suiza