[Differential indications for non-opioids for postoperative analgesia III. Analgesic effect of perioperative administration of metamizole plus diclofenac after spinal anesthesia]. / Untersuchungen zum differenzierten Einsatz von Nichtopioiden zur postoperativen Analgesie III. Analgetischer Effekt einer perioperativen Gabe von Metamizol plus Dicllofenac nach Spinalanästhesien.
Anasthesiol Intensivmed Notfallmed Schmerzther
; 32(8): 496-501, 1997 Aug.
Article
in De
| MEDLINE
| ID: mdl-9376465
ABSTRACT
PURPOSE:
In a previous study we investigated the analgesic efficacy of a combination of metamizol plus diclofenac after general anaesthesia. After minor orthopaedic surgery postoperative opioid requirements were reduced by 73% during the first 24 h after surgery. In the present study, we have investigated the efficacy of this analgesic combination after minor orthopaedic operations performed in spinal anaesthesia.METHODS:
Seventy four patients, scheduled for minor orthopaedic surgery, participated in this double-blind, randomised, placebo-controlled study. The setting was comparable to our previous study. Before induction of spinal anaesthesia, verum-treated patients received a diclofenac suppository (100 mg), and metamizol (1 g/100 ml NaCl 0.9% intravenously over 15 min). These infusions were repeated at 6 h and 12 h. In addition to the third infusion, the patients received a further diclofenac suppository (100 mg). Cumulated doses of buprenorphine (PCA, patient-controlled analgesia), pain scores (0-10), blood pressure, heart rate and side effects were recorded during the first 6 h and again at 24 h.RESULTS:
After spinal anaesthesia had subsided, all patients required increasing doses of buprenorphine. Verum-treated patients required significantly lower doses during the first 24 h after surgery (median -29%).CONCLUSIONS:
The combination of metamizol and diclofenac causes a clinically relevant reduction in opioid requirements after minor orthopaedic surgery in spinal anaesthesia.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pain, Postoperative
/
Anti-Inflammatory Agents, Non-Steroidal
/
Diclofenac
/
Dipyrone
/
Anesthesia, Spinal
Type of study:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
De
Journal:
Anasthesiol Intensivmed Notfallmed Schmerzther
Journal subject:
ANESTESIOLOGIA
/
MEDICINA DE EMERGENCIA
/
TERAPIA INTENSIVA
Year:
1997
Document type:
Article