Evidence for TGF-beta-mediated 'defense' of the glomerulus: a blackguard molecule rehabilitated?
Exp Nephrol
; 6(1): 1-6, 1998.
Article
in En
| MEDLINE
| ID: mdl-9523166
ABSTRACT
Transforming growth factor beta (TGF-beta) has been regarded as a 'blackguard molecule' that induces glomerular diseases. During the process of glomerulonephritis, upregulated TGF-beta stimulates the production of extracellular matrix and inhibits its degradation, leading to excessive matrix deposition. On the other hand, TGF-beta has the potential to be anti-inflammatory via inhibition of mitogenesis and production of inflammatory mediators by glomerular cells. This molecule strongly inactivates infiltrating cells, especially macrophages, which play a pivotal role in the generation of glomerular injury. The aim of this article is to summarize the potentially beneficial action of TGF-beta in the glomerulus and to address its 'bright side' in glomerular inflammation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Transforming Growth Factor beta
/
Kidney Diseases
/
Kidney Glomerulus
Limits:
Animals
/
Humans
Language:
En
Journal:
Exp Nephrol
Journal subject:
NEFROLOGIA
Year:
1998
Document type:
Article
Affiliation country:
Reino Unido