Personality correlates of +/- pindolol induced decreases in prolactin.
Pharmacopsychiatry
; 31(1): 19-24, 1998 Jan.
Article
in En
| MEDLINE
| ID: mdl-9524980
ABSTRACT
The present study was conducted to investigate if personality traits can be usefully related to serotonergic vs. dopaminergic action of the 5-HT1a-antagonist +/- pindolol. Forty healthy male volunteers (aged between 20 and 30 years) were randomly assigned to a placebo or a +/- pindolol (30 mg, oral dose) group in a double blind trial. Blood samples were drawn and analyzed for PRL concentrations. In addition, the subjects completed questionnaires on personality. The results indicated that +/- pindolol decreases PRL concentrations depending on personality. While subjects high on impulsivity and related traits (aggression and disinhibition) show lower PRL decreases, well-being and personality traits frequently related to dopaminergic activity were not correlated with changes in PRL. Since reduced (blunted) PRL-responses after 5-HT challenge tests have been reported for impulsives, the present results favor the involvement of primarily serotonergic and probably only secondarily dopaminergic control of +/- pindolol induced PRL decreases.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Personality
/
Pindolol
/
Serotonin Antagonists
/
Adrenergic beta-Antagonists
Type of study:
Clinical_trials
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Pharmacopsychiatry
Year:
1998
Document type:
Article