Hyperalgesia and allodynia induced by intrathecal (RS)-dihydroxyphenylglycine in rats.
Neuroreport
; 9(6): 1169-72, 1998 Apr 20.
Article
in En
| MEDLINE
| ID: mdl-9601688
ABSTRACT
To investigate the role of Group I mGluRs in allodynia and hyperalgesia, we examined the behavioural responses of rats to noxious and non-noxious mechanical and thermal stimuli following intrathecal (i.t.) treatment (25 nmol) with the selective mGluR1/5 agonist, (RS)-dihydroxyphenylglycine ((RS)-DHPG). (RS)-DHPG administration produced a persistent decrease in response latency on a 48 degrees C hotplate, a reduction in the 50% response threshold to von Frey hairs, and an increase in responses to a tail pinch. These data suggest that activation of spinal mGluR1/5 receptors plays a role in the development of persistent allodynia and hyperalgesia associated with tissue or nerve injury.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Behavior, Animal
/
Catechols
/
Pain Threshold
/
Receptors, Metabotropic Glutamate
/
Glycine
/
Hyperalgesia
Limits:
Animals
Language:
En
Journal:
Neuroreport
Journal subject:
NEUROLOGIA
Year:
1998
Document type:
Article
Affiliation country:
Canadá