Circulating levels in serum of total sialic acid, lipid-associated sialic acid, and fucose in precancerous lesion and cancer of the oral cavity.
Cancer Detect Prev
; 22(3): 237-40, 1998.
Article
in En
| MEDLINE
| ID: mdl-9618045
ABSTRACT
Total sialic acid (TSA), lipid-associated sialic acid (LASA), and fucose were estimated in sera of 35 patients with precancerous lesion of the oral cavity, 68 patients with cancer of the oral cavity, and 25 age- and sex-matched non-chewers of both tobacco and betal nut and nonsmokers as controls. Significant elevation in the serum levels of TSA and LASA were observed in patients with the precancerous and cancer lesions when compared with the controls. Serum TSA levels were elevated significantly in patients with cancer when compared with those with precancerous lesions. Circulating TSA and LASA levels were found to reflect tumor burden and correlated well with stage of the disease. However, serum fucose levels did not show an increase corresponding to stage of the disease. The results suggests that combined evaluation of these markers may be useful in predicting early malignant change and also in assessing the spread and invasiveness of the disease in cancer of the oral cavity.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Precancerous Conditions
/
Mouth Neoplasms
/
Carcinoma, Squamous Cell
/
Biomarkers, Tumor
/
N-Acetylneuraminic Acid
/
Fucose
/
Lipids
Type of study:
Risk_factors_studies
Limits:
Humans
Language:
En
Journal:
Cancer Detect Prev
Year:
1998
Document type:
Article
Affiliation country:
India