Effects of fumonisin B1 in pregnant rats.
Food Chem Toxicol
; 36(5): 397-408, 1998 May.
Article
in En
| MEDLINE
| ID: mdl-9662415
ABSTRACT
Fumonisin B1 (FB1), the major mycotoxin from Fusarium moniliforme, has been implicated as a causative agent in several animal and human diseases. Despite animal toxicity studies and human epidemiological studies of FB1, knowledge of its reproductive effects is scarce. In this study, one of a series of proposed studies that will allow extrapolation to humans, pregnant rats were given oral doses of 0, 1.875, 3.75, 7.5 or 15 mg FB1/kg on gestation days 3 16. Caesarean sections were performed on day 17 or 20, and maternal condition, implantation efficiency, foetal viability and foetal development were measured. Dose-related decreases in overall feed consumption and body weight gain were seen, but only the feed consumption decrease at 15 mg/kg, and the decreased body weight gain at 15 mg/kg on days 0-17 were statistically significant. Foetal body weights at day 17 were similar in control and treated groups; but in day-20 foetuses, female weight and crown-rump length were significantly decreased at 15 mg/kg. FB1 was not teratogenic at the doses tested, and no dose-related effects were seen in either skeletal or soft-tissue development. In day-17 animals, maternal and foetal brain, liver and kidney tissues, and maternal serum were preserved to study the levels of sphinganine (Sa), sphingosine (So), and the Sa/So ratios. Dose-related increases were seen in Sa/So ratios in maternal livers, kidneys and serum. Sa/So ratios of maternal brains were not affected, nor were those of foetal kidneys, livers or brains.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Teratogens
/
Abnormalities, Drug-Induced
/
Carboxylic Acids
/
Fumonisins
/
Embryonic and Fetal Development
Limits:
Animals
/
Pregnancy
Language:
En
Journal:
Food Chem Toxicol
Year:
1998
Document type:
Article
Affiliation country:
Estados Unidos